MersV1, Main, Exploration, bibRecord, 000B78

Structural Biology of the Arterivirus nsp11 Endoribonucleases.

Identifieur interne : 000B78 ( Main/Exploration ); précédent : 000B77; suivant : 000B79

Structural Biology of the Arterivirus nsp11 Endoribonucleases.

Auteurs : Manfeng Zhang [République populaire de Chine] ; Xiaorong Li [République populaire de Chine] ; Zengqin Deng [République populaire de Chine] ; Zhenhang Chen [République populaire de Chine] ; Yang Liu [République populaire de Chine] ; Yina Gao [République populaire de Chine] ; Wei Wu [République populaire de Chine] ; Zhongzhou Chen [République populaire de Chine]

Source :

Journal of virology [ 1098-5514 ] ; 2017.

RBID : pubmed:27795409

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Catalytic Domain, Conserved Sequence, Crystallography, X-Ray, Endoribonucleases (chemistry), Endoribonucleases (genetics), Endoribonucleases (metabolism), Equartevirus (chemistry), Equartevirus (enzymology), Escherichia coli (genetics), Escherichia coli (metabolism), Gene Expression, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (metabolism), Models, Molecular, Mutation, Porcine respiratory and reproductive syndrome virus (chemistry), Porcine respiratory and reproductive syndrome virus (enzymology), Protein Domains, Protein Multimerization, Protein Structure, Secondary, Recombinant Proteins (chemistry), Recombinant Proteins (genetics), Recombinant Proteins (metabolism), SARS Virus (chemistry), SARS Virus (genetics), SARS Virus (metabolism), Sequence Alignment, Viral Nonstructural Proteins (chemistry), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism).
MESH :
- chemical , chemistry : Endoribonucleases, Recombinant Proteins, Viral Nonstructural Proteins.
- chemical , genetics : Endoribonucleases, Recombinant Proteins, Viral Nonstructural Proteins.
- chemical , metabolism : Endoribonucleases, Recombinant Proteins, Viral Nonstructural Proteins.
- chemistry : Equartevirus, Middle East Respiratory Syndrome Coronavirus, Porcine respiratory and reproductive syndrome virus, SARS Virus.
- enzymology : Equartevirus, Porcine respiratory and reproductive syndrome virus.
- genetics : Escherichia coli, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- metabolism : Escherichia coli, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- Amino Acid Sequence, Catalytic Domain, Conserved Sequence, Crystallography, X-Ray, Gene Expression, Models, Molecular, Mutation, Protein Domains, Protein Multimerization, Protein Structure, Secondary, Sequence Alignment.

Abstract

Endoribonuclease (NendoU) is unique and conserved as a major genetic marker in nidoviruses that infect vertebrate hosts. Arterivirus nonstructural protein 11 (nsp11) was shown to have NendoU activity and play essential roles in the viral life cycle. Here, we report three crystal structures of porcine reproductive and respiratory syndrome virus (PRRSV) and equine arteritis virus (EAV) nsp11 mutants. The structures of arterivirus nsp11 contain two conserved compact domains: the N-terminal domain (NTD) and C-terminal domain (CTD). The structures of PRRSV and EAV endoribonucleases are similar and conserved in the arterivirus, but they are greatly different from that of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoV), representing important human pathogens in the Nidovirales order. The catalytic center of NendoU activity is located in the CTD, where a positively charged groove is next to the key catalytic residues conserved in nidoviruses. Although the NTD is nearly identical, the catalytic region of the arterivirus nsp11 family proteins is remarkably flexible, and the oligomerization may be concentration dependent. In summary, our structures provide new insight into this key multifunctional NendoU family of proteins and lay a foundation for better understanding of the molecular mechanism and antiviral drug development.

DOI: 10.1128/JVI.01309-16
PubMed: 27795409

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structural Biology of the Arterivirus nsp11 Endoribonucleases.</title>
<author><name sortKey="Zhang, Manfeng" sort="Zhang, Manfeng" uniqKey="Zhang M" first="Manfeng" last="Zhang">Manfeng Zhang</name>
<affiliation wicri:level="3"><nlm:affiliation>Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Xiaorong" sort="Li, Xiaorong" uniqKey="Li X" first="Xiaorong" last="Li">Xiaorong Li</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Zengqin" sort="Deng, Zengqin" uniqKey="Deng Z" first="Zengqin" last="Deng">Zengqin Deng</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Zhenhang" sort="Chen, Zhenhang" uniqKey="Chen Z" first="Zhenhang" last="Chen">Zhenhang Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, Yina" sort="Gao, Yina" uniqKey="Gao Y" first="Yina" last="Gao">Yina Gao</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Wei" sort="Wu, Wei" uniqKey="Wu W" first="Wei" last="Wu">Wei Wu</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Zhongzhou" sort="Chen, Zhongzhou" uniqKey="Chen Z" first="Zhongzhou" last="Chen">Zhongzhou Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China chenzhongzhou@cau.edu.cn.</nlm:affiliation>
<country wicri:rule="url">République populaire de Chine</country>
<wicri:regionArea>Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:27795409</idno>
<idno type="pmid">27795409</idno>
<idno type="doi">10.1128/JVI.01309-16</idno>
<idno type="wicri:Area/PubMed/Corpus">000F16</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F16</idno>
<idno type="wicri:Area/PubMed/Curation">000F16</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F16</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000B18</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B18</idno>
<idno type="wicri:Area/Ncbi/Merge">001823</idno>
<idno type="wicri:Area/Ncbi/Curation">001823</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001823</idno>
<idno type="wicri:Area/Main/Merge">000B81</idno>
<idno type="wicri:Area/Main/Curation">000B78</idno>
<idno type="wicri:Area/Main/Exploration">000B78</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Structural Biology of the Arterivirus nsp11 Endoribonucleases.</title>
<author><name sortKey="Zhang, Manfeng" sort="Zhang, Manfeng" uniqKey="Zhang M" first="Manfeng" last="Zhang">Manfeng Zhang</name>
<affiliation wicri:level="3"><nlm:affiliation>Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Xiaorong" sort="Li, Xiaorong" uniqKey="Li X" first="Xiaorong" last="Li">Xiaorong Li</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deng, Zengqin" sort="Deng, Zengqin" uniqKey="Deng Z" first="Zengqin" last="Deng">Zengqin Deng</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Zhenhang" sort="Chen, Zhenhang" uniqKey="Chen Z" first="Zhenhang" last="Chen">Zhenhang Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, Yina" sort="Gao, Yina" uniqKey="Gao Y" first="Yina" last="Gao">Yina Gao</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Wei" sort="Wu, Wei" uniqKey="Wu W" first="Wei" last="Wu">Wei Wu</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Zhongzhou" sort="Chen, Zhongzhou" uniqKey="Chen Z" first="Zhongzhou" last="Chen">Zhongzhou Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China chenzhongzhou@cau.edu.cn.</nlm:affiliation>
<country wicri:rule="url">République populaire de Chine</country>
<wicri:regionArea>Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Catalytic Domain</term>
<term>Conserved Sequence</term>
<term>Crystallography, X-Ray</term>
<term>Endoribonucleases (chemistry)</term>
<term>Endoribonucleases (genetics)</term>
<term>Endoribonucleases (metabolism)</term>
<term>Equartevirus (chemistry)</term>
<term>Equartevirus (enzymology)</term>
<term>Escherichia coli (genetics)</term>
<term>Escherichia coli (metabolism)</term>
<term>Gene Expression</term>
<term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term>
<term>Middle East Respiratory Syndrome Coronavirus (genetics)</term>
<term>Middle East Respiratory Syndrome Coronavirus (metabolism)</term>
<term>Models, Molecular</term>
<term>Mutation</term>
<term>Porcine respiratory and reproductive syndrome virus (chemistry)</term>
<term>Porcine respiratory and reproductive syndrome virus (enzymology)</term>
<term>Protein Domains</term>
<term>Protein Multimerization</term>
<term>Protein Structure, Secondary</term>
<term>Recombinant Proteins (chemistry)</term>
<term>Recombinant Proteins (genetics)</term>
<term>Recombinant Proteins (metabolism)</term>
<term>SARS Virus (chemistry)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (metabolism)</term>
<term>Sequence Alignment</term>
<term>Viral Nonstructural Proteins (chemistry)</term>
<term>Viral Nonstructural Proteins (genetics)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme)</term>
<term>Cristallographie aux rayons X</term>
<term>Domaine catalytique</term>
<term>Domaines protéiques</term>
<term>Endoribonucleases ()</term>
<term>Endoribonucleases (génétique)</term>
<term>Endoribonucleases (métabolisme)</term>
<term>Escherichia coli (génétique)</term>
<term>Escherichia coli (métabolisme)</term>
<term>Expression des gènes</term>
<term>Modèles moléculaires</term>
<term>Multimérisation de protéines</term>
<term>Mutation</term>
<term>Protéines recombinantes ()</term>
<term>Protéines recombinantes (génétique)</term>
<term>Protéines recombinantes (métabolisme)</term>
<term>Protéines virales non structurales ()</term>
<term>Protéines virales non structurales (génétique)</term>
<term>Protéines virales non structurales (métabolisme)</term>
<term>Structure secondaire des protéines</term>
<term>Séquence conservée</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (métabolisme)</term>
<term>Virus du syndrome respiratoire et reproducteur porcin ()</term>
<term>Virus du syndrome respiratoire et reproducteur porcin (enzymologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Endoribonucleases</term>
<term>Recombinant Proteins</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Endoribonucleases</term>
<term>Recombinant Proteins</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Endoribonucleases</term>
<term>Recombinant Proteins</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Equartevirus</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>Porcine respiratory and reproductive syndrome virus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus du syndrome respiratoire et reproducteur porcin</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Equartevirus</term>
<term>Porcine respiratory and reproductive syndrome virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Escherichia coli</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Endoribonucleases</term>
<term>Escherichia coli</term>
<term>Protéines recombinantes</term>
<term>Protéines virales non structurales</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Escherichia coli</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Endoribonucleases</term>
<term>Escherichia coli</term>
<term>Protéines recombinantes</term>
<term>Protéines virales non structurales</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Catalytic Domain</term>
<term>Conserved Sequence</term>
<term>Crystallography, X-Ray</term>
<term>Gene Expression</term>
<term>Models, Molecular</term>
<term>Mutation</term>
<term>Protein Domains</term>
<term>Protein Multimerization</term>
<term>Protein Structure, Secondary</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Cristallographie aux rayons X</term>
<term>Domaine catalytique</term>
<term>Domaines protéiques</term>
<term>Endoribonucleases</term>
<term>Expression des gènes</term>
<term>Modèles moléculaires</term>
<term>Multimérisation de protéines</term>
<term>Mutation</term>
<term>Protéines recombinantes</term>
<term>Protéines virales non structurales</term>
<term>Structure secondaire des protéines</term>
<term>Séquence conservée</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS</term>
<term>Virus du syndrome respiratoire et reproducteur porcin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Endoribonuclease (NendoU) is unique and conserved as a major genetic marker in nidoviruses that infect vertebrate hosts. Arterivirus nonstructural protein 11 (nsp11) was shown to have NendoU activity and play essential roles in the viral life cycle. Here, we report three crystal structures of porcine reproductive and respiratory syndrome virus (PRRSV) and equine arteritis virus (EAV) nsp11 mutants. The structures of arterivirus nsp11 contain two conserved compact domains: the N-terminal domain (NTD) and C-terminal domain (CTD). The structures of PRRSV and EAV endoribonucleases are similar and conserved in the arterivirus, but they are greatly different from that of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoV), representing important human pathogens in the Nidovirales order. The catalytic center of NendoU activity is located in the CTD, where a positively charged groove is next to the key catalytic residues conserved in nidoviruses. Although the NTD is nearly identical, the catalytic region of the arterivirus nsp11 family proteins is remarkably flexible, and the oligomerization may be concentration dependent. In summary, our structures provide new insight into this key multifunctional NendoU family of proteins and lay a foundation for better understanding of the molecular mechanism and antiviral drug development.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Manfeng" sort="Zhang, Manfeng" uniqKey="Zhang M" first="Manfeng" last="Zhang">Manfeng Zhang</name>
</noRegion>
<name sortKey="Chen, Zhenhang" sort="Chen, Zhenhang" uniqKey="Chen Z" first="Zhenhang" last="Chen">Zhenhang Chen</name>
<name sortKey="Chen, Zhongzhou" sort="Chen, Zhongzhou" uniqKey="Chen Z" first="Zhongzhou" last="Chen">Zhongzhou Chen</name>
<name sortKey="Deng, Zengqin" sort="Deng, Zengqin" uniqKey="Deng Z" first="Zengqin" last="Deng">Zengqin Deng</name>
<name sortKey="Gao, Yina" sort="Gao, Yina" uniqKey="Gao Y" first="Yina" last="Gao">Yina Gao</name>
<name sortKey="Li, Xiaorong" sort="Li, Xiaorong" uniqKey="Li X" first="Xiaorong" last="Li">Xiaorong Li</name>
<name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<name sortKey="Wu, Wei" sort="Wu, Wei" uniqKey="Wu W" first="Wei" last="Wu">Wei Wu</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B78 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B78 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:27795409
   |texte=   Structural Biology of the Arterivirus nsp11 Endoribonucleases.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27795409" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

Serveur d'exploration MERS

Structural Biology of the Arterivirus nsp11 Endoribonucleases.

Structural Biology of the Arterivirus nsp11 Endoribonucleases.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.